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Human FBXO11 activation kit by CRISPRa

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SKU
GA112864
FBXO11 CRISPRa kit - CRISPR gene activation of human F-box protein 11
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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RC222041 FBXO11 (Myc-DDK-tagged)-Human F-box protein 11 (FBXO11), transcript variant 1
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Other products for "FBXO11"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol FBXO11
Locus ID 80204
Components

GA112864G1, FBXO11 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA112864G2, FBXO11 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA112864G3, FBXO11 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001190274, NM_012167, NM_018693, NM_025133
UniProt ID Q86XK2
Synonyms FBX11; PRMT9; UBR6; UG063H01; VIT1
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. provided by RefSeq, Jun 2010
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Documents
Resources
Other Versions
SKU Description Size Price
KN422041 FBXO11 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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