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Human DNAJB14 activation kit by CRISPRa

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SKU
GA112771
DNAJB14 CRISPRa kit - CRISPR gene activation of human DnaJ heat shock protein family (Hsp40) member B14
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA336037 Rabbit Polyclonal Anti-DNAJB14 Antibody
100 ul
$585.00
RC204615 DNAJB14 (Myc-DDK-tagged)-Human DnaJ (Hsp40) homolog, subfamily B, member 14 (DNAJB14), transcript variant 1
10 ug
$457.00

Other products for "DNAJB14"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol DNAJB14
Locus ID 79982
Components

GA112771G1, DNAJB14 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA112771G2, DNAJB14 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA112771G3, DNAJB14 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001031723, NM_001278310, NM_001278311, NM_024920
UniProt ID Q8TBM8
Synonyms EGNR9427; PRO34683
Summary Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:24732912). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities (PubMed:24732912). Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN404615 DNAJB14 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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