Human GDAP1L1 activation kit by CRISPRa

SKU GA112298

GDAP1L1 CRISPRa kit - CRISPR gene activation of human ganglioside induced differentiation associated protein 1 like 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: GDAP1L1
• Locus ID: 78997
• Components:

  GA112298G1, GDAP1L1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA112298G2, GDAP1L1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA112298G3, GDAP1L1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001256737, NM_001256738, NM_001256739, NM_001256740, NM_024034, NR_046353
• UniProt ID: Q96MZ0
• Synonyms: dJ881L22.1; dJ995J12.1.1
• Summary: The ganglioside GD3 synthase causes cell differentiation with neurite sprouting when transfected into the mouse neuroblastoma cell line Neuro2a. After differentiation, the expression of several genes is upregulated, including one that encodes a protein termed ganglioside-induced differentiation-associated protein 1 (Gdap1). A similar gene was found in humans, and mutations in the human gene are associated with Charcot-Marie-Tooth type 4A disease. The protein encoded by this gene is similar in sequence to the human GDAP1 protein. Several transcript variants encoding different isoforms, as well as a noncoding transcript variant, have been found for this gene. [provided by RefSeq, Feb 2012]