Human CIAO3 activation kit by CRISPRa

SKU GA112078

CIAO3 CRISPRa kit - CRISPR gene activation of human cytosolic iron-sulfur assembly component 3

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: CIAO3
• Locus ID: 64428
• Components:

  GA112078G1, CIAO3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA112078G2, CIAO3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA112078G3, CIAO3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001304799, NM_022493
• UniProt ID: Q9H6Q4
• Synonyms: HPRN; IOP1; LET1L; NAR1; PRN
• Summary: Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect.[UniProtKB/Swiss-Prot Function]