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Human NSD1 activation kit by CRISPRa

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SKU
GA112038
NSD1 CRISPRa kit - CRISPR gene activation of human nuclear receptor binding SET domain protein 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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100 ul
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RC221517 NSD1 (Myc-DDK-tagged)-Human nuclear receptor binding SET domain protein 1 (NSD1), transcript variant 2
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Other products for "NSD1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol NSD1
Locus ID 64324
Components

GA112038G1, NSD1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA112038G2, NSD1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA112038G3, NSD1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_022455, NM_172349, NM_001365684
UniProt ID Q96L73
Synonyms ARA267; KMT3B; SOTOS; SOTOS1; STO
Summary This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Multiple transcript variants encoding distinct isoforms have been identified for this gene. provided by RefSeq, Sep 2018
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Documents
Resources
Other Versions
SKU Description Size Price
KN418297 NSD1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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