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Human SEMA4A activation kit by CRISPRa

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SKU
GA112016
SEMA4A CRISPRa kit - CRISPR gene activation of human semaphorin 4A
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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100 ul
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RC202231 SEMA4A (Myc-DDK-tagged)-Human sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A (SEMA4A), transcript variant 1
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Other products for "SEMA4A"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol SEMA4A
Locus ID 64218
Components

GA112016G1, SEMA4A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA112016G2, SEMA4A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA112016G3, SEMA4A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001193300, NM_001193301, NM_001193302, NM_022367, NM_001370567, NM_001370569, NM_001370571, NM_001370568
UniProt ID Q9H3S1
Synonyms CORD10; RP35; SEMAB; SEMB
Summary This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.provided by RefSeq, Sep 2010
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Documents
Resources
Other Versions
SKU Description Size Price
KN402231 SEMA4A - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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