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Human SLAMF7 activation kit by CRISPRa

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SKU
GA111740
SLAMF7 CRISPRa kit - CRISPR gene activation of human SLAM family member 7
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA807414 SLAMF7 mouse monoclonal antibody, clone OTI3B3 (formerly 3B3) 100 ul
$447.00
RC220985 SLAMF7 (Myc-DDK-tagged)-Human SLAM family member 7 (SLAMF7)
10 ug
$686.00

Other products for "SLAMF7"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol SLAMF7
Locus ID 57823
Components

GA111740G1, SLAMF7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA111740G2, SLAMF7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA111740G3, SLAMF7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001282588, NM_001282589, NM_001282590, NM_001282591, NM_001282592, NM_001282593, NM_001282594, NM_001282595, NM_001282596, NM_021181
UniProt ID Q9NQ25
Synonyms 19A; CD319; CRACC; CS1
Summary Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN220985 SLAMF7 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN220985BN SLAMF7 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN220985LP SLAMF7 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN220985RB SLAMF7 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN420985 SLAMF7 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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