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Human USP37 activation kit by CRISPRa

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SKU
GA111690
USP37 CRISPRa kit - CRISPR gene activation of human ubiquitin specific peptidase 37
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA372082 USP37 rabbit polyclonal antibody
100 ul
$310.00
RC223407 USP37 (Myc-DDK-tagged)-Human ubiquitin specific peptidase 37 (USP37)
10 ug
$896.00

Other products for "USP37"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol USP37
Locus ID 57695
Components

GA111690G1, USP37 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA111690G2, USP37 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA111690G3, USP37 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_020935
UniProt ID Q86T82
Synonyms KIAA1594; MGC117261
Summary Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN423407 USP37 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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