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Human ALS2 activation kit by CRISPRa

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SKU
GA111678
ALS2 CRISPRa kit - CRISPR gene activation of human alsin Rho guanine nucleotide exchange factor ALS2
  $1,657.00
4 Weeks*

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Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol ALS2
Locus ID 57679
Components

GA111678G1, ALS2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA111678G2, ALS2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA111678G3, ALS2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001135745, NM_020919
UniProt ID Q96Q42
Synonyms ALS2CR6; ALSJ; IAHSP; PLSJ
Summary The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Oct 2008
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Other Versions
SKU Description Size Price
KN415448 ALS2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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