Human SCYL1 activation kit by CRISPRa

SKU GA111487

SCYL1 CRISPRa kit - CRISPR gene activation of human SCY1 like pseudokinase 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: SCYL1
• Locus ID: 57410
• Components:

  GA111487G1, SCYL1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA111487G2, SCYL1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA111487G3, SCYL1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001048218, NM_020680
• UniProt ID: Q96KG9
• Synonyms: GKLP; HT019; NKTL; NTKL; P105; TAPK; TEIF; TRAP
• Summary: This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]