Human SENP7 activation kit by CRISPRa

SKU GA111469

SENP7 CRISPRa kit - CRISPR gene activation of human SUMO specific peptidase 7

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: SENP7
• Locus ID: 57337
• Components:

  GA111469G1, SENP7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA111469G2, SENP7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA111469G3, SENP7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001077203, NM_001282801, NM_001282802, NM_001282803, NM_001282804, NM_020654
• UniProt ID: Q9BQF6
• Synonyms: KIAA1707; MGC157730
• Summary: The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]