Human FTSJD1 (CMTR2) activation kit by CRISPRa

SKU GA110965

CMTR2 CRISPRa kit - CRISPR gene activation of human cap methyltransferase 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: CMTR2
• Locus ID: 55783
• Components:

  GA110965G1, FTSJD1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA110965G2, FTSJD1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA110965G3, FTSJD1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001099642, NM_001324374, NM_001324377, NM_001324378, NM_001324379, NM_018348
• UniProt ID: Q8IYT2
• Synonyms: AFT; FTSJD1; HMTr2; MTr2
• Summary: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs.[UniProtKB/Swiss-Prot Function]