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Human LYAR activation kit by CRISPRa

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SKU
GA110850
LYAR CRISPRa kit - CRISPR gene activation of human Ly1 antibody reactive
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA378173 LYAR Rabbit polyclonal Antibody
100 ul
$410.00
RC201908L4V Lenti ORF particles, LYAR (mGFP-tagged) - Human Ly1 antibody reactive homolog (mouse) (LYAR), transcript variant 1, 200ul, >10^7 TU/mL
200 ul
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Other products for "LYAR"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol LYAR
Locus ID 55646
Components

GA110850G1, LYAR gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA110850G2, LYAR gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA110850G3, LYAR gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001145725, NM_017816
UniProt ID Q9NX58
Synonyms ZC2HC2; ZLYAR
Summary Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227). Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580). Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity). Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN401908 LYAR - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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