Human SMPD4 activation kit by CRISPRa

SKU GA110836

SMPD4 CRISPRa kit - CRISPR gene activation of human sphingomyelin phosphodiesterase 4

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: SMPD4
• Locus ID: 55627
• Components:

  GA110836G1, SMPD4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA110836G2, SMPD4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA110836G3, SMPD4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001171083, NM_001171084, NM_017751, NM_017951, NR_033230, NR_033231, NR_033232
• UniProt ID: Q9NXE4
• Synonyms: NET13; NSMASE-3; NSMASE3
• Summary: The protein encoded by this gene is a sphingomyelinase that catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. This gene is activated by DNA damage, cellular stress, and tumor necrosis factor, but it is downregulated by wild-type p53. The encoded protein localizes to the endoplasmic reticulum and Golgi network. [provided by RefSeq, Mar 2017]