Human Protor 1 (PRR5) activation kit by CRISPRa

SKU GA110825

PRR5 CRISPRa kit - CRISPR gene activation of human proline rich 5

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PRR5
• Locus ID: 55615
• Components:

  GA110825G1, Protor 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA110825G2, Protor 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA110825G3, Protor 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001017528, NM_001017529, NM_001017530, NM_001198721, NM_015366, NM_181333
• UniProt ID: P85299
• Synonyms: FLJ20185k; PP610; PROTOR-1; PROTOR1
• Summary: This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]