Human VPS50 activation kit by CRISPRa

SKU GA110820

VPS50 CRISPRa kit - CRISPR gene activation of human VPS50 subunit of EARP/GARPII complex

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: VPS50
• Locus ID: 55610
• Components:

  GA110820G1, VPS50 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA110820G2, VPS50 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA110820G3, VPS50 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001257998, NM_017667, NM_024553
• UniProt ID: Q96JG6
• Summary: Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).[UniProtKB/Swiss-Prot Function]