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Human IMPACT activation kit by CRISPRa

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SKU
GA110739
IMPACT CRISPRa kit - CRISPR gene activation of human impact RWD domain protein
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC204631 IMPACT (Myc-DDK-tagged)-Human Impact homolog (mouse) (IMPACT)
10 ug
$300.00

Other products for "IMPACT"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol IMPACT
Locus ID 55364
Components

GA110739G1, IMPACT gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA110739G2, IMPACT gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA110739G3, IMPACT gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_018439
UniProt ID Q9P2X3
Synonyms RWDD5
Summary Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.UniProtKB/Swiss-Prot Function
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Documents
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Other Versions
SKU Description Size Price
KN404631 IMPACT - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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