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Human DIP13B (APPL2) activation kit by CRISPRa

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SKU
GA110597
APPL2 CRISPRa kit - CRISPR gene activation of human adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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$447.00
RC207506 APPL2 (Myc-DDK-tagged)-Human adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (APPL2)
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Other products for "APPL2"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol APPL2
Locus ID 55198
Components

GA110597G1, DIP13B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA110597G2, DIP13B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA110597G3, DIP13B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001251904, NM_001251905, NM_018171
UniProt ID Q8NEU8
Synonyms DIP13B
Summary The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. provided by RefSeq, Oct 2011
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Documents
Resources
Other Versions
SKU Description Size Price
KN407506 APPL2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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