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Human QRICH1 activation kit by CRISPRa

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SKU
GA110328
QRICH1 CRISPRa kit - CRISPR gene activation of human glutamine rich 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA362455 QRICH1 Antibody - middle region
100 ul
$585.00
RC213114 QRICH1 (Myc-DDK-tagged)-Human glutamine-rich 1 (QRICH1), transcript variant 1
10 ug
$711.00

Other products for "QRICH1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol QRICH1
Locus ID 54870
Components

GA110328G1, QRICH1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA110328G2, QRICH1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA110328G3, QRICH1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001320580, NM_001320581, NM_001320582, NM_001320583, NM_001320584, NM_001320585, NM_017730, NM_198880
UniProt ID Q2TAL8
Summary Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress (PubMed:33384352). Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway (PubMed:33384352). ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR (PubMed:33384352). May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability (PubMed:33384352). Upregulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver (PubMed:33384352). Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth (PubMed:30281152).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN411088 QRICH1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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