Human NSMCE4A activation kit by CRISPRa

SKU
GA110258
NSMCE4A CRISPRa kit - CRISPR gene activation of human NSE4 homolog A, SMC5-SMC6 complex component
  $1,657.00
4 Weeks*
Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol NSMCE4A
Locus ID 54780
Components

GA110258G1, NSMCE4A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA110258G2, NSMCE4A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA110258G3, NSMCE4A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001167865, NM_017615
UniProt ID Q9NXX6
Synonyms C10orf86; NS4EA; NSE4A
Summary Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus.UniProtKB/Swiss-Prot Function
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Other Versions
SKU Description Size Price
KN409357 NSMCE4A - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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