Human MAGEL2 activation kit by CRISPRa

SKU GA110175

MAGEL2 CRISPRa kit - CRISPR gene activation of human MAGE family member L2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: MAGEL2
• Locus ID: 54551
• Components:

  GA110175G1, MAGEL2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA110175G2, MAGEL2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA110175G3, MAGEL2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_019066
• UniProt ID: Q9UJ55
• Synonyms: NDNL1; nM15; PWLS; SHFYNG
• Summary: Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS. [provided by RefSeq, Oct 2010]