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Human DCUN1D1 activation kit by CRISPRa

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SKU
GA110070
DCUN1D1 CRISPRa kit - CRISPR gene activation of human defective in cullin neddylation 1 domain containing 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA311491 Goat Anti-DCUN1D1 Antibody
100 ug
$565.00
RC203427 DCUN1D1 (Myc-DDK-tagged)-Human DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) (DCUN1D1)
10 ug
$300.00

Other products for "DCUN1D1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol DCUN1D1
Locus ID 54165
Components

GA110070G1, DCUN1D1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA110070G2, DCUN1D1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA110070G3, DCUN1D1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001308101, NM_020640
UniProt ID Q96GG9
Synonyms DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3
Summary Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483). Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN403427 DCUN1D1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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