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Human MTLRP (GHRL) activation kit by CRISPRa

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SKU
GA109968
GHRL CRISPRa kit - CRISPR gene activation of human ghrelin and obestatin prepropeptide
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC206989 GHRL (Myc-DDK-tagged)-Human ghrelin/obestatin prepropeptide (GHRL), transcript variant 1
10 ug
$150.00

Other products for "GHRL"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol GHRL
Locus ID 51738
Components

GA109968G1, MTLRP gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA109968G2, MTLRP gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA109968G3, MTLRP gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001134941, NM_001134944, NM_001134945, NM_001134946, NM_001302821, NM_001302822, NM_001302823, NM_001302824, NM_001302825, NM_016362, NR_024132, NR_024133, NR_024134, NR_024135, NR_024136, NR_024137, NR_024138, NR_126505
UniProt ID Q9UBU3
Synonyms MTLRP
Summary This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alternative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression. provided by RefSeq, Nov 2014
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Documents
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Other Versions
SKU Description Size Price
KN406989 GHRL - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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