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Human OAZ3 activation kit by CRISPRa

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SKU
GA109941
OAZ3 CRISPRa kit - CRISPR gene activation of human ornithine decarboxylase antizyme 3
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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RC229129 OAZ3 (Myc-DDK-tagged)-Human ornithine decarboxylase antizyme 3 (OAZ3), transcript variant 1
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Other products for "OAZ3"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol OAZ3
Locus ID 51686
Components

GA109941G1, OAZ3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA109941G2, OAZ3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA109941G3, OAZ3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001134939, NM_001301371, NM_016178
UniProt ID Q9UMX2
Summary The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake; however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. Alternatively spliced transcript variants encoding different isoforms, including one resulting from the use of non-AUG (CUG) translation initiation codon, have been found for this gene. provided by RefSeq, Dec 2014
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Documents
Resources
Other Versions
SKU Description Size Price
KN420490 OAZ3 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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