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Human PTRH2 activation kit by CRISPRa

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SKU
GA109923
PTRH2 CRISPRa kit - CRISPR gene activation of human peptidyl-tRNA hydrolase 2
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA369292 PTRH2 rabbit polyclonal antibody
100 ul
$310.00
RC201462 PTRH2 (Myc-DDK-tagged)-Human peptidyl-tRNA hydrolase 2 (PTRH2), nuclear gene encoding mitochondrial protein
10 ug
$300.00

Other products for "PTRH2"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol PTRH2
Locus ID 51651
Components

GA109923G1, PTRH2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA109923G2, PTRH2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA109923G3, PTRH2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001015509, NM_016077
UniProt ID Q9Y3E5
Synonyms BIT1; CFAP37; CGI-147; IMNEPD; PTH; PTH 2; PTH2
Summary The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos. After loss of cell attachment to the ECM, this protein is phosphorylated, is released from the mitochondria into the cytosol, and promotes caspase-independent apoptosis through interactions with transcriptional regulators. This gene has been implicated in the development and progression of tumors, and mutations in this gene have been associated with an infantile multisystem neurologic, endocrine, and pancreatic disease (INMEPD) characterized by intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency (PMID: 25574476). Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Mar 2015
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Documents
Resources
Other Versions
SKU Description Size Price
KN401462 PTRH2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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