Human GNL2 activation kit by CRISPRa

SKU GA109292

GNL2 CRISPRa kit - CRISPR gene activation of human G protein nucleolar 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: GNL2
• Locus ID: 29889
• Components:

  GA109292G1, GNL2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA109292G2, GNL2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA109292G3, GNL2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001323623, NM_001323624, NM_013285
• UniProt ID: Q13823
• Synonyms: HUMAUANTIG; Ngp-1; NGP1; Nog2; Nug2
• Summary: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195).[UniProtKB/Swiss-Prot Function]