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Human NPC1L1 activation kit by CRISPRa

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SKU
GA109286
NPC1L1 CRISPRa kit - CRISPR gene activation of human NPC1 like intracellular cholesterol transporter 1
  $1,657.00
4 Weeks*

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Other products for "NPC1L1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol NPC1L1
Locus ID 29881
Components

GA109286G1, NPC1L1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA109286G2, NPC1L1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA109286G3, NPC1L1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001101648, NM_001300967, NM_013389
UniProt ID Q9UHC9
Synonyms NPC11L1
Summary The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Oct 2009
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Documents
Resources
Other Versions
SKU Description Size Price
KN420597 NPC1L1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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