Human UBN1 activation kit by CRISPRa

SKU GA109284

UBN1 CRISPRa kit - CRISPR gene activation of human ubinuclein 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: UBN1
• Locus ID: 29855
• Components:

  GA109284G1, UBN1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA109284G2, UBN1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA109284G3, UBN1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001079514, NM_001288656, NM_016936
• UniProt ID: Q9NPG3
• Synonyms: VT; VT4
• Summary: Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016]