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Human BLNK activation kit by CRISPRa

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SKU
GA109259
BLNK CRISPRa kit - CRISPR gene activation of human B cell linker
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA808517 BLNK mouse monoclonal antibody, clone OTI4C9 (formerly 4C9) 100 ul
$447.00
RC202488 BLNK (Myc-DDK-tagged)-Human B-cell linker (BLNK), transcript variant 1
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Other products for "BLNK"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol BLNK
Locus ID 29760
Components

GA109259G1, BLNK gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA109259G2, BLNK gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA109259G3, BLNK gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001114094, NM_001258440, NM_001258441, NM_001258442, NM_013314, NR_047680, NR_047681, NR_047682, NR_047683
UniProt ID Q8WV28
Synonyms AGM4; BASH; bca; BLNK-S; LY57; SLP-65; SLP65
Summary This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. provided by RefSeq, May 2012
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Documents
Resources
Other Versions
SKU Description Size Price
KN402488 BLNK - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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