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Human UHRF1 activation kit by CRISPRa

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SKU
GA109258
UHRF1 CRISPRa kit - CRISPR gene activation of human ubiquitin like with PHD and ring finger domains 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA325077 UHRF1 Antibody (Center)
400 ul
$645.00
RC214251 UHRF1 (Myc-DDK-tagged)-Human ubiquitin-like with PHD and ring finger domains 1 (UHRF1), transcript variant 2
10 ug
$738.00

Other products for "UHRF1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol UHRF1
Locus ID 29128
Components

GA109258G1, UHRF1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA109258G2, UHRF1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA109258G3, UHRF1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001048201, NM_001290050, NM_001290051, NM_001290052, NM_013282
UniProt ID Q96T88
Synonyms hNP95; hUHRF1; huNp95; ICBP90; Np95; RNF106
Summary This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. provided by RefSeq, Feb 2014
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Documents
Resources
Other Versions
SKU Description Size Price
KN414251 UHRF1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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