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Human SIGLEC8 activation kit by CRISPRa

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SKU
GA109056
SIGLEC8 CRISPRa kit - CRISPR gene activation of human sialic acid binding Ig like lectin 8
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA351666 Rabbit Polyclonal Anti-SIGLEC8 Antibody
100 ul
$205.00
RC208582 SIGLEC8 (Myc-DDK-tagged)-Human sialic acid binding Ig-like lectin 8 (SIGLEC8)
10 ug
$686.00

Other products for "SIGLEC8"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol SIGLEC8
Locus ID 27181
Components

GA109056G1, SIGLEC8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA109056G2, SIGLEC8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA109056G3, SIGLEC8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_014442, NM_001363548
UniProt ID Q9NYZ4
Synonyms SAF2; SIGLEC-8; SIGLEC8L
Summary Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 PubMed 11095983).supplied by OMIM, May 2010
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Documents
Resources
Other Versions
SKU Description Size Price
KN408582 SIGLEC8 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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