Human SERBP1 activation kit by CRISPRa

SKU GA108767

SERBP1 CRISPRa kit - CRISPR gene activation of human SERPINE1 mRNA binding protein 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: SERBP1
• Locus ID: 26135
• Components:

  GA108767G1, SERBP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA108767G2, SERBP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA108767G3, SERBP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001018067, NM_001018068, NM_001018069, NM_015640
• UniProt ID: Q8NC51
• Synonyms: CGI-55; CHD3IP; HABP4L; PAI-RBP1; PAIRBP1
• Summary: May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation (PubMed:28695742).[UniProtKB/Swiss-Prot Function]