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Human APPL (APPL1) activation kit by CRISPRa

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SKU
GA108731
APPL1 CRISPRa kit - CRISPR gene activation of human adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA807768 APPL1 mouse monoclonal antibody,clone OTI4B11 100 ul
$447.00
RC206021 APPL1 (Myc-DDK-tagged)-Human adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1)
10 ug
$649.00

Other products for "APPL1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol APPL1
Locus ID 26060
Components

GA108731G1, APPL gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA108731G2, APPL gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA108731G3, APPL gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_012096
UniProt ID Q9UKG1
Synonyms APPL; DIP13alpha; MODY14
Summary The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
KN406021 APPL1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

file-alt Citations

APPL1 promotes glucose uptake in response to mechanical stretch via the PKCζ-non-muscle myosin IIa pathway in C2C12 myotubes
Saito, Okada, Shimoda et al
Cell. Signal. (2016) 28 (11), 1694-1702 DOI: 10.1016/j.cellsig.2016.07.010
Cited by 14
AI Summary: OriGene’s full-length human APPL1 plasmid (pCMV6-XL4 vector) was used to overexpress APPL1 in C2C12 myotubes, enabling the study of its role in promoting glucose uptake in response to mechanical stretch.
Snippet: Frederick, MD, USA). The full-length human APPL1 inserted into the pCMV6-XL4 plasmid vector was from OriGene Technology, Inc. (Rockville, MD, USA). Elastic silicone chambers were from Strex, Inc. (Osaka, Japan). Compound C ... Cite SaveSaving
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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