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Human SENP6 activation kit by CRISPRa

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SKU
GA108726
SENP6 CRISPRa kit - CRISPR gene activation of human SUMO specific peptidase 6
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC211809 SENP6 (Myc-DDK-tagged)-Human SUMO1/sentrin specific peptidase 6 (SENP6), transcript variant 1
10 ug
$968.00

Other products for "SENP6"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol SENP6
Locus ID 26054
Components

GA108726G1, SENP6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA108726G2, SENP6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA108726G3, SENP6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001100409, NM_001304792, NM_015571
UniProt ID Q9GZR1
Synonyms SSP1; SUSP1
Summary Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 PubMed 10799485). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 PubMed 18799455).supplied by OMIM, Jun 2009
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Documents
Resources
Other Versions
SKU Description Size Price
KN411809 SENP6 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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