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Human GPR124 (ADGRA2) activation kit by CRISPRa

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SKU
GA108659
ADGRA2 CRISPRa kit - CRISPR gene activation of human adhesion G protein-coupled receptor A2
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA351229 Rabbit Polyclonal Anti-GPR124 Antibody
100 ul
$205.00
RC229431 GPR124 (Myc-DDK-tagged)-Human G protein-coupled receptor 124 (GPR124)
10 ug
$1,716.00

Other products for "ADGRA2"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol ADGRA2
Locus ID 25960
Components

GA108659G1, GPR124 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA108659G2, GPR124 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA108659G3, GPR124 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_032777
UniProt ID Q96PE1
Synonyms GPR124; TEM5
Summary Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628).UniProtKB/Swiss-Prot Function
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Other Versions
SKU Description Size Price
KN416183 ADGRA2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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