Human RAB3GAP2 activation kit by CRISPRa

SKU GA108533

RAB3GAP2 CRISPRa kit - CRISPR gene activation of human RAB3 GTPase activating non-catalytic protein subunit 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: RAB3GAP2
• Locus ID: 25782
• Components:

  GA108533G1, RAB3GAP2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA108533G2, RAB3GAP2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA108533G3, RAB3GAP2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_012414, N93244
• UniProt ID: Q9H2M9
• Synonyms: p150; RAB3-GAP150; RAB3GAP150; SPG69; WARBM2
• Summary: The protein encoded by this gene belongs to the RAB3 protein family, members of which are involved in regulated exocytosis of neurotransmitters and hormones. This protein forms the Rab3 GTPase-activating complex with RAB3GAP1, where it constitutes the regulatory subunit, whereas the latter functions as the catalytic subunit. This gene has the highest level of expression in the brain, consistent with it having a key role in neurodevelopment. Mutations in this gene are associated with Martsolf syndrome.[provided by RefSeq, Oct 2009]