Human BRD1 activation kit by CRISPRa

SKU GA108499

BRD1 CRISPRa kit - CRISPR gene activation of human bromodomain containing 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: BRD1
• Locus ID: 23774
• Components:

  GA108499G1, BRD1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA108499G2, BRD1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA108499G3, BRD1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001304808, NM_001304809, NM_014577, NM_001349940, NM_001349941, NM_001349942, NR_146334, NR_146335
• UniProt ID: O95696
• Synonyms: BRL; BRPF1; BRPF2
• Summary: This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schizophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]