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Human HAAO activation kit by CRISPRa

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SKU
GA108344
HAAO CRISPRa kit - CRISPR gene activation of human 3-hydroxyanthranilate 3,4-dioxygenase
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA306802 Rabbit Polyclonal HAAO Antibody
100 ug
$640.00
RC206273 HAAO (Myc-DDK-tagged)-Human 3-hydroxyanthranilate 3,4-dioxygenase (HAAO)
10 ug
$300.00

Other products for "HAAO"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol HAAO
Locus ID 23498
Components

GA108344G1, HAAO gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA108344G2, HAAO gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA108344G3, HAAO gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_012205
UniProt ID P46952
Synonyms 3-HAO; HAO
Summary 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
KN406273 HAAO - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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