Human Dicer (DICER1) activation kit by CRISPRa

SKU GA108284

DICER1 CRISPRa kit - CRISPR gene activation of human dicer 1, ribonuclease III

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: DICER1
• Locus ID: 23405
• Components:

  GA108284G1, Dicer gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA108284G2, Dicer gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA108284G3, Dicer gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001195573, NM_001271282, NM_001291628, NM_030621, NM_177438
• UniProt ID: Q9UPY3
• Synonyms: DCR1; Dicer; Dicer1e; HERNA; K12H4.8-LIKE; MNG1; RMSE2
• Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]