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Human NEDD4 2 (NEDD4L) activation kit by CRISPRa

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SKU
GA108222
NEDD4L CRISPRa kit - CRISPR gene activation of human NEDD4 like E3 ubiquitin protein ligase
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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100 ul
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Other products for "NEDD4L"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol NEDD4L
Locus ID 23327
Components

GA108222G1, NEDD4 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA108222G2, NEDD4 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA108222G3, NEDD4 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001144964, NM_001144965, NM_001144966, NM_001144967, NM_001144968, NM_001144969, NM_001144970, NM_001144971, NM_001243960, NM_015277
UniProt ID Q96PU5
Synonyms hNEDD4-2; NEDD4-2; NEDD4.2; RSP5
Summary This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. provided by RefSeq, Mar 2012
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Documents
Resources
Other Versions
SKU Description Size Price
KN217897 NEDD4L - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN217897BN NEDD4L - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN217897LP NEDD4L - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN217897RB NEDD4L - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN417897 NEDD4L - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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