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Human TTLL12 activation kit by CRISPRa

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SKU
GA108092
TTLL12 CRISPRa kit - CRISPR gene activation of human tubulin tyrosine ligase like 12
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA500789 Anti-TTLL12 mouse monoclonal antibody, clone OTI4B2 (formerly 4B2) 100 ul
$447.00
RC200841 TTLL12 (Myc-DDK-tagged)-Human tubulin tyrosine ligase-like family, member 12 (TTLL12)
10 ug
$599.00

Other products for "TTLL12"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol TTLL12
Locus ID 23170
Components

GA108092G1, TTLL12 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA108092G2, TTLL12 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA108092G3, TTLL12 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_015140
UniProt ID Q14166
Synonyms dJ526I14.2
Summary Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473). Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473). During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935).UniProtKB/Swiss-Prot Function
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Other Versions
SKU Description Size Price
KN400841 TTLL12 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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