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Human SCN11A activation kit by CRISPRa

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SKU
GA107775
SCN11A CRISPRa kit - CRISPR gene activation of human sodium voltage-gated channel alpha subunit 11
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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100 ul
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RC219309 SCN11A (Myc-DDK-tagged)-Human sodium channel, voltage-gated, type XI, alpha subunit (SCN11A)
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Other products for "SCN11A"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol SCN11A
Locus ID 11280
Components

GA107775G1, SCN11A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA107775G2, SCN11A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA107775G3, SCN11A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001287223, NM_014139, NM_001349253
UniProt ID Q9UI33
Synonyms FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A; SNS-2
Summary Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is highly expressed in nociceptive neurons of dorsal root ganglia and trigeminal ganglia. It mediates brain-derived neurotrophic factor-evoked membrane depolarization and is a major effector of peripheral inflammatory pain hypersensitivity. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy type VII and familial episodic pain syndrome-3. Alternative splicing results in multiple transcript variants. provided by RefSeq, Mar 2017
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Documents
Resources
Other Versions
SKU Description Size Price
KN419309 SCN11A - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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