Human PDCD10 activation kit by CRISPRa

SKU GA107740

PDCD10 CRISPRa kit - CRISPR gene activation of human programmed cell death 10

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PDCD10
• Locus ID: 11235
• Components:

  GA107740G1, PDCD10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA107740G2, PDCD10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA107740G3, PDCD10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_007217, NM_145859, NM_145860
• UniProt ID: Q9BUL8
• Synonyms: CCM3; TFAR15
• Summary: This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]