Human WDR45 activation kit by CRISPRa

SKU GA107674

WDR45 CRISPRa kit - CRISPR gene activation of human WD repeat domain 45

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: WDR45
• Locus ID: 11152
• Components:

  GA107674G1, WDR45 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA107674G2, WDR45 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA107674G3, WDR45 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001029896, NM_007075
• UniProt ID: Q9Y484
• Synonyms: JM5; NBIA4; NBIA5; WDRX1; WIPI-4; WIPI4
• Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008]