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Human ADAMTS13 activation kit by CRISPRa

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SKU
GA107626
ADAMTS13 CRISPRa kit - CRISPR gene activation of human ADAM metallopeptidase with thrombospondin type 1 motif 13
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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RC220320 ADAMTS13 (Myc-DDK-tagged)-Human ADAM metallopeptidase with thrombospondin type 1 motif, 13 (ADAMTS13), transcript variant 1
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Other products for "ADAMTS13"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol ADAMTS13
Locus ID 11093
Components

GA107626G1, ADAMTS13 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA107626G2, ADAMTS13 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA107626G3, ADAMTS13 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_017587, NM_139025, NM_139026, NM_139027, NM_139028, NR_024514
UniProt ID Q76LX8
Synonyms ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP; VWFCP
Summary This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. provided by RefSeq, Jul 2013
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Documents
Resources
Other Versions
SKU Description Size Price
KN417385 ADAMTS13 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

file-alt Citations

VWF and ADAMTS13 behavior in estradiol-treated HUVEC
Powazniak, Kempfer, Pereyra et al
Eur. J. Haematol. (2011) 86 (2), 140-7 DOI: 10.1111/j.1600-0609.2010.01545.x
Cited by 13
AI Summary: OriGene contributed Human ADAMTS13 shRNA (29-mer) and control plasmids, which were used to knock down ADAMTS13 expression in HUVEC and study its effect on VWF synthesis and secretion in response to estradiol treatment.
Snippet: ICI-182780 (Fulvestrant) is the first in a new class of novel, steroidal, 'pure' antiestrogens – the estrogen receptor down-regulators. ... Human ADAMTS13 shRNA (29-mer) and control plasmids were purchased from Origene (Rockville, MD, USA) and used according to the
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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