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Human CPSF30 (CPSF4) activation kit by CRISPRa

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SKU
GA107468
CPSF4 CRISPRa kit - CRISPR gene activation of human cleavage and polyadenylation specific factor 4
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA349825 Rabbit Polyclonal Anti-CPSF4 Antibody
100 ul
$205.00
RC200532 CPSF4 (Myc-DDK-tagged)-Human cleavage and polyadenylation specific factor 4, 30kDa (CPSF4), transcript variant 2
10 ug
$300.00

Other products for "CPSF4"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol CPSF4
Locus ID 10898
Components

GA107468G1, CPSF30 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA107468G2, CPSF30 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA107468G3, CPSF30 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001081559, NM_001318160, NM_001318161, NM_001318162, NM_006693
UniProt ID O95639
Synonyms CPSF30; NAR; NEB-1; NEB1
Summary Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
KN400532 CPSF4 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

file-alt Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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