Human PGC1 alpha (PPARGC1A) activation kit by CRISPRa

SKU
GA107462
PPARGC1A CRISPRa kit - CRISPR gene activation of human PPARG coactivator 1 alpha
  $1,657.00
4 Weeks*
Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol PPARGC1A
Locus ID 10891
Components

GA107462G1, PGC1 alpha gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA107462G2, PGC1 alpha gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA107462G3, PGC1 alpha gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001330751, NM_001330752, NM_001330753, NM_013261, NM_001354825, NM_001354826, NM_001354827, NM_001354828, NR_148981, NR_148982, NR_148983, NR_148984, NR_148985, NR_148986, NR_148987
UniProt ID Q9UBK2
Synonyms LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v; PGC1; PGC1A; PPARGC1
Summary The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. provided by RefSeq, Jul 2008
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Documents
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Other Versions
SKU Description Size Price
KN212244 PPARGC1A - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN212244BN PPARGC1A - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN212244LP PPARGC1A - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN212244RB PPARGC1A - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN412244 PPARGC1A - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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