Human MEKK2 (MAP3K2) activation kit by CRISPRa

SKU GA107364

MAP3K2 CRISPRa kit - CRISPR gene activation of human mitogen-activated protein kinase kinase kinase 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: MAP3K2
• Locus ID: 10746
• Components:

  GA107364G1, MEKK2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA107364G2, MEKK2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA107364G3, MEKK2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_006609
• UniProt ID: Q9Y2U5
• Synonyms: MEKK2; MEKK2B
• Summary: The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]