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Human KHDRBS3 activation kit by CRISPRa

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SKU
GA107304
KHDRBS3 CRISPRa kit - CRISPR gene activation of human KH RNA binding domain containing, signal transduction associated 3
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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100 ul
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RC209824 KHDRBS3 (Myc-DDK-tagged)-Human KH domain containing, RNA binding, signal transduction associated 3 (KHDRBS3)
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Other products for "KHDRBS3"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol KHDRBS3
Locus ID 10656
Components

GA107304G1, KHDRBS3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA107304G2, KHDRBS3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA107304G3, KHDRBS3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_006558
UniProt ID O75525
Synonyms Etle; etoile; SALP; SLM-2; SLM2; T-STAR; TSTAR
Summary RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-AUUAAA-3' motif in vitro. Binds optimally to RNA containing 5'-AUUAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:10564820, PubMed:19561594, PubMed:26758068). Involved in splice site selection of vascular endothelial growth factor (PubMed:15901763). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members (PubMed:26758068). Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity (By similarity). May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing (By similarity). Can bind FABP9 mRNA (By similarity). May play a role as a negative regulator of cell growth. Inhibits cell proliferation.UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN409824 KHDRBS3 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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