Human GPNMB activation kit by CRISPRa

SKU GA107133

GPNMB CRISPRa kit - CRISPR gene activation of human glycoprotein nmb

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: GPNMB
• Locus ID: 10457
• Components:

  GA107133G1, GPNMB gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA107133G2, GPNMB gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA107133G3, GPNMB gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001005340, NM_002510
• UniProt ID: Q14956
• Synonyms: HGFIN; NMB
• Summary: The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]